Research

Precise synaptic connectivity is essential for proper information processing in neural circuits. Understanding how the extraordinary specificity of neural wiring is achieved and maintained is important, as changes in connectivity, composition and function of synapses are thought to underlie memory processes and brain disorders such as autism and Alzheimer’s disease.

Our research focuses on the role of cell-surface interactions in specifying synaptic connectivity. Our main objectives are to understand how neurons form synapses with their appropriate partners; how synapses are differentiated into distinct types of synapses, and how synaptic connectivity is affected by pathological conditions. Elucidating the molecular mechanisms that specify and maintain the synaptic network will not only increase our understanding of neural circuit formation, function and dysfunction; the implication of many cell-surface proteins in brain disorders, combined with their accessible localization, also makes them potential therapeutic targets.